C₄₇H₅₉Cl₂F₄N₇O₁₅P₂

Base Information

• Chemical Name: C₄₇H₅₉Cl₂F₄N₇O₁₅P₂
• CAS No.: 932725-90-1
• Molecular Formula: C₄₇H₅₉Cl₂F₄N₇O₁₅P₂
• Molecular Weight: 1170.87
• Mol file: 932725-90-1.mol

Synonyms:C₄₇H₅₉Cl₂F₄N₇O₁₅P₂

Chemical Property of C₄₇H₅₉Cl₂F₄N₇O₁₅P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₉Cl₂F₄N₇O₁₅P₂

There total 21 articles about C₄₇H₅₉Cl₂F₄N₇O₁₅P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H26ClF2N4O6P + 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester (932725-89-8) → C47H59Cl2F4N7O15P2 (932725-90-1)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 0.666667h;

DOI:10.1021/jm061146x

Reference yield:

C10H9Cl2F2O3P → C47H59Cl2F4N7O15P2 (932725-90-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

3.1: 69 percent / Me₃SnOH / 1,2-dichloro-ethane / 3 h / Heating

4.1: 0.32 g / PyBOP; DIEA / CH₂Cl₂ / 1 h / 0 - 20 °C

5.1: 94 percent / aq. LiOH / tetrahydrofuran

6.1: 0.090 g / PyBOP; DIEA / CH₂Cl₂; tetrahydrofuran / 0.67 h / 0 - 20 °C

With lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trimethyltin(IV) hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm061146x

Reference yield:

methyl 4-[diethyl phosphono(difluoromethyl)]phenylacetate (932725-73-0) → C47H59Cl2F4N7O15P2 (932725-90-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: CH₂Cl₂ / 18 h

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

3.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

4.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

5.1: 69 percent / Me₃SnOH / 1,2-dichloro-ethane / 3 h / Heating

6.1: 0.32 g / PyBOP; DIEA / CH₂Cl₂ / 1 h / 0 - 20 °C

7.1: 94 percent / aq. LiOH / tetrahydrofuran

8.1: 0.090 g / PyBOP; DIEA / CH₂Cl₂; tetrahydrofuran / 0.67 h / 0 - 20 °C

With lithium hydroxide; oxalyl dichloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trimethyltin(IV) hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm061146x

upstream raw materials:

4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester

methyl 4-[diethyl phosphono(difluoromethyl)]phenylacetate

methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate