methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Base Information

Chemical Name:methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate
CAS No.:880596-26-9
Molecular Formula:C₂₀H₂₄ClF₂N₂O₇P
Molecular Weight:508.843
Hs Code.:

Synonyms:methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

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Chemical Property of methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

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Technology Process of methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

There total 7 articles about methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 880595-47-1
methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

: 2493-04-1
(5-nitrofuran-2-yl)methanol

: 880596-26-9
methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Guidance literature:: (5-nitrofuran-2-yl)methanol; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate; In tetrahydrofuran; at -78 ℃; for 10h;
DOI:10.1021/jm061146x

Reference yield:

: C₁₀H₉Cl₂F₂O₃P

: 880596-26-9
methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm061146x

Reference yield:

: 932725-73-0
methyl 4-[diethyl phosphono(difluoromethyl)]phenylacetate

: 880596-26-9
methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: CH₂Cl₂ / 18 h

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

3.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

4.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm061146x