3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid

Base Information

Chemical Name:3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid
CAS No.:1229441-30-8
Molecular Formula:C₂₇H₂₃Cl₂N₅O₅
Molecular Weight:568.416
Hs Code.:

Synonyms:3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid

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Chemical Property of 3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid

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Technology Process of 3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid

There total 1 articles about 3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1229441-30-8
3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 0.08 h / 20 °C

1.2: 2 h / 50 °C

2.1: water; sulfuric acid; sodium nitrite / 1.67 h / Reflux

3.1: potassium carbonate / acetonitrile / Reflux

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 80 °C / Schlenk technique; Inert atmosphere

5.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Schlenk technique; Inert atmosphere

6.1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 24 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; sulfuric acid; water; potassium acetate; potassium carbonate; caesium carbonate; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; acetonitrile; 5.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00829

Reference yield: 70.0%

: 1229441-30-8
3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid

: 765-30-0
Cyclopropylamine

: 1229441-31-9
N-cyclopropyl-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/acs.jmedchem.6b00829