N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide
CAS No.:1397714-31-6
Molecular Formula:C₁₁H₁₃ClFNOS
Molecular Weight:261.748
Hs Code.:

Synonyms:N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

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Chemical Property of N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

There total 1 articles about N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96516-31-3
2-chloro-3-fluoro-benzaldehyde

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 1397714-31-6
N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

Guidance literature:: With titanium(IV)isopropoxide; In dichloromethane; for 3h; Reflux;

Reference yield:

: 79-20-9
acetic acid methyl ester

: 1397714-31-6
N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

: 1397714-32-7
(S)-3-(2-chloro-3-fluorophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)propionic acid methyl ester

: (R)-3-(2-chloro-3-fluorophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)propionic acid methyl ester

Guidance literature:: acetic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -75 - 0 ℃; for 1h;

N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide; With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; for 0.5h;

N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide; In tetrahydrofuran; hexane; at -75 ℃; for 3h;

Reference yield:

: 1397714-31-6
N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide

: 1213185-15-9
(S)-3-amino-3-(3-chloro-2-fluorophenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -75 - 0 °C

1.2: 0.5 h

1.3: 3 h / -75 °C

2.1: acetyl chloride / methanol / 1 h / 20 °C

With n-butyllithium; diisopropylamine; acetyl chloride; In tetrahydrofuran; methanol;