7-chloro-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-sulfonamide

Base Information

• Chemical Name: 7-chloro-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-sulfonamide
• CAS No.: 23380-53-2
• Molecular Formula: C8H5 Cl N2 O5 S
• Molecular Weight: 276.657
• Hs Code.: 2935009090
• European Community (EC) Number: 811-480-3
• UNII: ET594CS2LG
• DSSTox Substance ID: DTXSID90539051
• Wikidata: Q82414669
• Mol file: 23380-53-2.mol

Synonyms:23380-53-2;7-chloro-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-sulfonamide;7-CHLORO-2,4-DIOXO-1H-3,1-BENZOXAZINE-6-SULFONAMIDE;7-CHLORO-2,4-DIOXO-1,4-DIHYDRO-2H-BENZO[D][1,3]OXAZINE-6-SULFONAMIDE;7-Chloro-2,4-dioxo-1,4-dihydro-2H-benzo-[d][1,3]oxazine-6-sulfonamide;7-Chloro-6-sulfamoylisatoic anhydride;ET594CS2LG;DTXSID90539051;A912684;7-chloro-2, 4-dioxo-1H-3, 1-benzoxazine-6-sulfonamide;7-Chloro-1,4-dihydro-2,4-dioxo-2H-3,1-benzoxazine-6-sulfonamide;7-Chloro-2,4-dioxo-1,4-dihydro-2H-3,1-benzoxazine-6-sulfonamide;2H-3,1-Benzoxazine-6-sulfonamide, 7-chloro-1,4-dihydro-2,4-dioxo-

Chemical Property of 7-chloro-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-sulfonamide

Chemical Property:

• Melting Point: 293 °C (decomp)
• Refractive Index: 1.642
• PKA: 8.97±0.20(Predicted)
• PSA: 131.61000
• Density: 1.759g/cm³
• LogP: 1.56320
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 275.9607701
• Heavy Atom Count: 17
• Complexity: 459

Purity/Quality:

99.9% ^*data from raw suppliers

7-Chloro-6-sulfamoylisatoicAnhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C2C(=CC(=C1S(=O)(=O)N)Cl)NC(=O)OC2=O
• Uses: 7-Chloro-6-sulfamoylisatoic Anhydride is an intermediate in the synthesis of 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide (A604420) and in the synthesis of 3-Aryl- and 3-?aralkyl-?1,?2,?3,?4-?tetrahydro-?4-?oxo-?6-?quinazolinesulfonamides.

Technology Process of 7-chloro-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-sulfonamide

There total 4 articles about 7-chloro-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-acetylamino-4-chloro-toluene-3-sulfonic acid amide (17560-53-1) → 7-chloro-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-sulfonic acid amide (23380-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium permanganate

2: hydrogenchloride

3: 1,4-dioxane

With 1,4-dioxane; hydrogenchloride; potassium permanganate;

Reference yield:

2-acetylamino-4-chloro-5-sulfamoyl-benzoic acid (17560-54-2) → 7-chloro-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-sulfonic acid amide (23380-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride

2: 1,4-dioxane

With 1,4-dioxane; hydrogenchloride;

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 4-chloro-5-sulfamoylanthranilic acid (3086-91-7) → 2-ethoxycarbonylamino-4-chloro-5-sulfamoyl-benzoic acid ethyl ester (108991-98-6) + 7-chloro-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-sulfonic acid amide (23380-53-2)

Guidance literature:

With 1,4-dioxane;

upstream raw materials:

chloroformic acid ethyl ester

4-chloro-5-sulfamoylanthranilic acid

6-acetylamino-4-chloro-toluene-3-sulfonic acid amide

2-acetylamino-4-chloro-5-sulfamoyl-benzoic acid

Downstream raw materials:

2-Amino-4-chloro-5-sulfamoylbenzamide

4-chloro-5-sulfamoyl-2-ureido-benzoic acid

4-chloro-2-(morpholine-4-carbonylamino)-5-sulfamoyl-benzoic acid