N-Benzyl-L-leucine

Base Information

• Chemical Name: N-Benzyl-L-leucine
• CAS No.: 2743-42-2
• Molecular Formula: C13H19 N O2
• Molecular Weight: 221.299
• Hs Code.: 2922499990
• Mol file: 2743-42-2.mol

Synonyms:Leucine,N-benzyl- (6CI,7CI); Leucine, N-benzyl-, L- (8CI); N-(Phenylmethyl)leucine;N-Benzyl-(S)-leucine; N-Benzyl-L-leucine; NSC 15853

Chemical Property of N-Benzyl-L-leucine

Chemical Property:

• Vapor Pressure: 1.72E-05mmHg at 25°C
• Boiling Point: 349.8°Cat760mmHg
• Flash Point: 165.3°C
• PSA: 49.33000
• Density: 1.058g/cm³
• LogP: 2.66640

Purity/Quality:

N-BENZYL-L-LEUCINE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Benzyl-L-leucine

There total 12 articles about N-Benzyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(benzylamino)-4-methylpentanoic acid (40297-72-1) → (S)-2-(benzylamino)-4-methylpentanoic acid (2743-42-2)

Guidance literature:

With C₂₄H₂₉CoN₂O₄; In dichloromethane; water; at 10 ℃; for 24h; optical yield given as %ee; Resolution of racemate;

DOI:10.1002/ejoc.200701101

Reference yield: 76.4%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + benzyl chloride (100-44-7) → (S)-2-(benzylamino)-4-methylpentanoic acid (2743-42-2)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 25h;

DOI:10.1080/00397910008087240

Reference yield: 64.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + benzaldehyde (100-52-7) → (S)-2-(benzylamino)-4-methylpentanoic acid (2743-42-2)

Guidance literature:

L-leucine; benzaldehyde; With sodium hydroxide; water; at 20 ℃;

With sodium tetrahydroborate; at 0 ℃;

DOI:10.1002/hlca.200390342

upstream raw materials:

(S)-Leu-OMe

benzaldehyde

L-leucine

benzyl chloride

Downstream raw materials:

N-benzyl-N-methyl-(S)-leucine

N-Nitroso-N-benzyl-L-leucin

(S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-4-methylpentanoic acid

methyl (S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-4-methylpentanoate