L-Leucine, N-methyl-N-(phenylmethyl)-

Base Information

• Chemical Name: L-Leucine, N-methyl-N-(phenylmethyl)-
• CAS No.: 60643-14-3
• Molecular Formula: C₁₄H₂₁NO₂
• Molecular Weight: 235.326
• DSSTox Substance ID: DTXSID40448886
• Wikidata: Q82268079
• Mol file: 60643-14-3.mol

Synonyms:L-Leucine, N-methyl-N-(phenylmethyl)-;N-benzyl-N-methyl-(S)-leucine;DTXSID40448886;N-Methyl-L-Leucine, derivative of;60643-14-3;Z2736972938

Chemical Property of L-Leucine, N-methyl-N-(phenylmethyl)-

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 235.157228913
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)N(C)CC1=CC=CC=C1
• Isomeric SMILES: CC(C)C[C@@H](C(=O)O)N(C)CC1=CC=CC=C1

Technology Process of L-Leucine, N-methyl-N-(phenylmethyl)-

There total 6 articles about L-Leucine, N-methyl-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-2-(benzylamino)-4-methylpentanoic acid (2743-42-2) → N-benzyl-N-methyl-(S)-leucine (60643-14-3)

Guidance literature:

With formic acid;

DOI:10.1002/hlca.19630460133

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → N-benzyl-N-methyl-(S)-leucine (60643-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄

2: HCOOH

With sodium tetrahydroborate; formic acid;

DOI:10.1016/S0960-894X(98)00156-5

Reference yield:

benzaldehyde (100-52-7) → N-benzyl-N-methyl-(S)-leucine (60643-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄

2: HCOOH

With sodium tetrahydroborate; formic acid;

DOI:10.1016/S0960-894X(98)00156-5

upstream raw materials:

formaldehyd

(S)-2-(benzylamino)-4-methylpentanoic acid

L-leucine

benzaldehyde