2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide

Base Information

• Chemical Name: 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide
• CAS No.: 909900-65-8
• Molecular Formula: C₁₂H₁₃NOS
• Molecular Weight: 219.307
• Mol file: 909900-65-8.mol

Synonyms:2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide

Chemical Property of 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide

There total 3 articles about 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

phenylmethanethiol (100-53-8) + 2-bromo-N-(prop-2-ynyl)acetamide (173208-24-7) → 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide (909900-65-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 16h;

DOI:10.1039/b607200c

Reference yield: 82.0%

methyl (benzylthio)acetate (17277-59-7) + Propargylamine (2450-71-7) → 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide (909900-65-8)

Guidance literature:

With CAL-B (Candida antarctica lipase B) immobilized on an acrylic resin (Novozyme 435); In tert-butyl methyl ether; at 45 ℃; for 4h; Schlenk technique; Enzymatic reaction;

DOI:10.1016/j.tetlet.2013.06.051

Reference yield:

S-benzylmercaptoacetic acid (103-46-8) + Propargylamine (2450-71-7) → 2-(benzylthio)-N-(prop-2-yn-1-yl)acetamide (909900-65-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1039/c7cc09642a

upstream raw materials:

phenylmethanethiol

2-bromo-N-(prop-2-ynyl)acetamide

methyl (benzylthio)acetate

Propargylamine

Downstream raw materials:

1-N-(3,4,6-tri-O-acetyl-2-deoxy-2-N-deoxy-N-acetyl-β-D-glucopyranosylamido)-4-(N'-methylidenyl-2'-thiobenzylacetamido)-4,5-anhydro-triazole