7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole

Base Information

• Chemical Name: 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole
• CAS No.: 1383851-10-2
• Molecular Formula: C₃₀H₂₉N
• Molecular Weight: 403.567
• Mol file: 1383851-10-2.mol

Synonyms:7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole

Chemical Property of 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole

There total 8 articles about 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

3,5-bis(2',6'-dimethylphenyl)-1-mesitylpyridin-1-ium trifluoromethanesulfonate (1383851-01-1) → 3,5-bis(2',6'-dimethylphenyl)-1-mesityl-1,2-dihydropyridine (1383851-08-8) + 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole (1383851-10-2)

Guidance literature:

With hydrogen; lithium hexamethyldisilazane; In toluene; at 50 ℃; for 5h; under 37503.8 Torr; Pressure; Inert atmosphere; Glovebox; Autoclave;

DOI:10.1002/anie.201503233

Reference yield: 22.0%

3,5-bis(2',6'-dimethylphenyl)-1-mesitylpyridin-1-ium trifluoromethanesulfonate (1383851-01-1) → 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole (1383851-10-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c2cc33184e

Reference yield:

CF3O3S(1-)*C27H24N3O4(1+) (1383850-99-4) → 7,9-bis(2,6-dimethylphenyl)-2,4-dimethylpyrido[1,2-a]indole (1383851-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.5 h / 150 °C / Neat (no solvent)

2: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1039/c2cc33184e

upstream raw materials:

3,5-dibromopyridine

3,5-bis(2',6'-dimethylphenyl)-1-mesitylpyridin-1-ium trifluoromethanesulfonate

3,5-bis(2,6-dimethylphenyl)pyridine

C₂₇H₂₄N₃O₄⁽¹⁺⁾*Cl^(1-)