benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

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Chemical Name:benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate
CAS No.:1416992-34-1
Molecular Formula:C₂₄H₃₃N₃O₅
Molecular Weight:443.543
Hs Code.:

Synonyms:benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

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Chemical Property of benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

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Technology Process of benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

There total 9 articles about benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1416992-27-2
C₂₄H₃₅N₃O₅

: 1416992-34-1
benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm5019934

Reference yield:

: 17193-39-4,144644-00-8
methyl 3-cyclohexyl-L-alaninate hydrochloride

: 1416992-34-1
benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane

2: triethylamine

3: lithium hydroxide; water / tetrahydrofuran

4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

5: lithium borohydride / tetrahydrofuran

6: Dess-Martin periodane / dichloromethane

With lithium borohydride; water; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.026

Reference yield:

: 113828-93-6
(S)-2-Benzyloxycarbonylamino-3-cyclohexyl-propionic acid methyl ester

: 1416992-34-1
benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide; water / tetrahydrofuran

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: lithium borohydride / tetrahydrofuran

4: Dess-Martin periodane / dichloromethane

With lithium borohydride; water; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.026