sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

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Chemical Name:sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
CAS No.:1416992-42-1
Molecular Formula:C₂₄H₃₄N₃O₈S*Na
Molecular Weight:547.605
Hs Code.:

Synonyms:sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

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Chemical Property of sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

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Technology Process of sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

There total 9 articles about sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1416992-34-1
benzyl ((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)carbamate

: 1416992-42-1
sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

Guidance literature:: With sodium hydrogensulfite; In ethanol; water; ethyl acetate; at 50 ℃; for 3h;
DOI:10.1021/jm5019934

Reference yield:

: 1416992-27-2
C₂₄H₃₅N₃O₅

: 1416992-42-1
sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane

2: sodium hydrogensulfite; water / ethanol; ethyl acetate / 2 h / 40 °C

With water; Dess-Martin periodane; sodium hydrogensulfite; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.11.026

Reference yield:

: 17193-39-4,144644-00-8
methyl 3-cyclohexyl-L-alaninate hydrochloride

: 1416992-42-1
sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-cyclohexylpropanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: 1,4-dioxane

2: triethylamine

3: lithium hydroxide; water / tetrahydrofuran

4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

5: lithium borohydride / tetrahydrofuran

6: Dess-Martin periodane / dichloromethane

7: sodium hydrogensulfite; water / ethanol; ethyl acetate / 2 h / 40 °C

With lithium borohydride; water; benzotriazol-1-ol; Dess-Martin periodane; sodium hydrogensulfite; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.026