1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

Base Information

Chemical Name:1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole
CAS No.:251369-17-2
Molecular Formula:C₃₁H₄₃ClN₄O₃
Molecular Weight:555.16
Hs Code.:

Synonyms:1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

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Chemical Property of 1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

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Technology Process of 1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

There total 10 articles about 1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 193626-88-9
1-(3-(4-piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

: 251369-17-2
1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 120 ℃; for 4h;
DOI:10.1016/S0040-4020(99)00683-3

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 251369-17-2
1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / hydrogen / Rh/C / ethanol / 24 h / 60 °C / 3102.89 Torr

2: 57 percent / potassium carbonate / tetrahydrofuran; H₂O / 5 - 20 °C

3: 90 percent / triphenylphosphine; bromine; pyridine / CH₂Cl₂

4: 74 percent / sodium hydride / dimethylformamide; various solvent(s) / 6 h / 60 °C

5: 89 percent / trifluoroacetic acid / 0.83 h / 20 °C

6: 64 percent / sodium bicarbonate / dimethylformamide / 4 h / 120 °C

With pyridine; hydrogen; bromine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; Rh on carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Acylation / 3: Bromination / 4: Alkylation / 5: Hydrolysis / 6: Alkylation;
DOI:10.1016/S0040-4020(99)00683-3

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 251369-17-2
1-(3-(4-(1-N-BOC-3-aminopropyl)piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / potassium carbonate / tetrahydrofuran; H₂O / 5 - 20 °C

2: 90 percent / triphenylphosphine; bromine; pyridine / CH₂Cl₂

3: 74 percent / sodium hydride / dimethylformamide; various solvent(s) / 6 h / 60 °C

4: 89 percent / trifluoroacetic acid / 0.83 h / 20 °C

5: 64 percent / sodium bicarbonate / dimethylformamide / 4 h / 120 °C

With pyridine; bromine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Acylation / 2: Bromination / 3: Alkylation / 4: Hydrolysis / 5: Alkylation;
DOI:10.1016/S0040-4020(99)00683-3