N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

Base Information

Chemical Name:N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide
CAS No.:160447-08-5
Molecular Formula:C₂₆H₄₇NO₅
Molecular Weight:453.663
Hs Code.:

Synonyms:N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

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Chemical Property of N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

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Technology Process of N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

There total 4 articles about N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104882-45-3
(S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

: 160447-09-6
(R)-4-(tert-butoxy)-2-(cyclopropylmethyl)-4-oxobutanoic acid

: 160447-08-5
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; Yield given;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 160447-08-5
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / LDA, DMPU / tetrahydrofuran / -78 °C / 1.) 1 h, 2.) 1.5 h

2: 30 percent H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

3: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 160447-06-3
3-(3-cyclopropyl-1-oxopropyl)-4(S)-(1-methylethyl)-2-oxazolidinone

: 160447-08-5
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / LDA, DMPU / tetrahydrofuran / -78 °C / 1.) 1 h, 2.) 1.5 h

2: 30 percent H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

3: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00265-X