4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Base Information

Chemical Name:4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
CAS No.:1432913-34-2
Molecular Formula:C₂₀H₁₁ClF₂N₆O₃S₂
Molecular Weight:520.928
Hs Code.:

Synonyms:4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Suppliers and Price of 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

There total 5 articles about 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1432912-70-3
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

: 1432913-34-2
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 15216-81-6
5-chloro-2-hydroxybenzoyl chloride

: 1432913-34-2
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux

3: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/acsmedchemlett.5b00447

Reference yield:

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1432913-34-2
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 1 h / Reflux

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

3: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux

4: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With dmap; thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.5b00447