4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Base Information

Chemical Name:4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
CAS No.:1432912-70-3
Molecular Formula:C₂₉H₂₁ClF₂N₆O₅S₂
Molecular Weight:671.105
Hs Code.:

Synonyms:4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

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Chemical Property of 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

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Technology Process of 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

There total 7 articles about 4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432912-53-2
4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenol

: 1235406-89-9
N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

: 1432912-70-3
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 16h;
DOI:10.1021/acsmedchemlett.5b00447

Reference yield:

: 15216-81-6
5-chloro-2-hydroxybenzoyl chloride

: 1432912-70-3
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux

3: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

With dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/acsmedchemlett.5b00447

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1432912-70-3
4-(4-chloro-2-(imidazo[1,5-a]pyrazin-3-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 16 h / Reflux; Dean-Stark

2: sodium tetrahydroborate / methanol / 16 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -78 - 20 °C

4: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;
DOI:10.1021/acsmedchemlett.5b00447