(Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one

Base Information

• Chemical Name: (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one
• CAS No.: 1627500-60-0
• Molecular Formula: C₁₆H₁₆Cl₂F₃NO₂
• Molecular Weight: 382.21
• Mol file: 1627500-60-0.mol

Synonyms:(Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one

Chemical Property of (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one

There total 10 articles about (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

tert-Butyl-[2,2-dichloro-hex-(E)-ylidene]-amine (56906-26-4) + 2-oxo-3-(4-(trifluoromethyl)phenyl)propanoyl chloride (1627500-64-4) → (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one (1627500-60-0)

Guidance literature:

tert-Butyl-[2,2-dichloro-hex-(E)-ylidene]-amine; 2-oxo-3-(4-(trifluoromethyl)phenyl)propanoyl chloride; In chloroform; at 0 - 20 ℃; Inert atmosphere;

With trifluoroacetic acid; at 50 ℃;

Reference yield: 13.6%

C15H21Cl2NO2 + 2-oxo-3-(4-(trifluoromethyl)phenyl)propanoyl chloride (1627500-64-4) → (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one (1627500-60-0)

Guidance literature:

C₁₅H₂₁Cl₂NO₂; 2-oxo-3-(4-(trifluoromethyl)phenyl)propanoyl chloride; With N-chloro-succinimide; L-proline; In dichloromethane; at 0 - 20 ℃; for 0.5h;

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 48h;

DOI:10.1002/anie.201402310

Reference yield:

tert-Butyl-[2,2-dichloro-hex-(E)-ylidene]-amine (56906-26-4) + C10H6ClF3O2 → (Z)-2-(1,1-di-chloropentyl)-5-(4-(trifluoromethyl)benzylidene)oxazolidin-4-one (1627500-60-0)

Guidance literature:

tert-Butyl-[2,2-dichloro-hex-(E)-ylidene]-amine; C₁₀H₆ClF₃O₂; In chloroform; at 0 - 20 ℃; Inert atmosphere;

With trifluoroacetic acid; at 50 ℃;

DOI:10.1039/c7cc03626d

upstream raw materials:

4-Trifluoromethylbenzaldehyde

2-oxo-3-(4-(trifluoromethyl)phenyl)propanoyl chloride

2-oxo-3-(4-(trifluoromethyl)phenyl)propanoic acid

4-methoxy-benzaldehyde

Refernces

• 1、 Edwards, Grant A.,Shymanska, Nataliia V.,Pierce, Joshua G.. "5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus". . p. 7353 - 7356. Retrieved 2017/07/11.