N-N-BUTYLACRYLAMIDE

Base Information

• Chemical Name: N-N-BUTYLACRYLAMIDE
• CAS No.: 2565-18-6
• Molecular Formula: C7H13 N O
• Molecular Weight: 127.186
• Hs Code.: 2924199090
• Mol file: 2565-18-6.mol

Synonyms:Acrylamide,N-butyl- (6CI,7CI,8CI); N-Butyl-2-propenamide; N-Butylacrylamide;N-n-Butylacrylamide

Chemical Property of N-N-BUTYLACRYLAMIDE

Chemical Property:

• Boiling Point: 83-85 °C(Press: 1 Torr)
• PKA: 15.13±0.46(Predicted)
• PSA: 29.10000
• Density: 0.876±0.06 g/cm3(Predicted)
• LogP: 1.47960
• Storage Temp.: 2-8°C

Purity/Quality:

98% (stabilized with MEHQ) ^*data from raw suppliers

N-butylprop-2-enamide ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-N-BUTYLACRYLAMIDE

There total 17 articles about N-N-BUTYLACRYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-butylamine (109-73-9,85404-21-3) + acryloyl chloride (814-68-6,25189-84-8) → N-butylacrylamide (2565-18-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1055/s-1998-1900

Reference yield: 95.0%

N-butyl-(3-methylthio)propionamide → N-butylacrylamide (2565-18-6)

Guidance literature:

With 1-chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2]octane bis(tetrafluoroborate); In 1,4-dioxane; at 100 ℃; for 8h; Temperature; Solvent;

Reference yield: 85.0%

3-Bromopropionic acid (590-92-1) + N-butylamine (109-73-9,85404-21-3) → N-butylacrylamide (2565-18-6)

Guidance literature:

Multistep reaction;

DOI:10.1081/SCC-120022176

upstream raw materials:

pyridine

3-chloro-propionic acid butylamide

N,N'-dibutyl-3-aminopropanamide

N,N-Dibutyl-cis-β-jodacrylamid

Downstream raw materials:

N-Butyl-3-phenylselanyl-propionamide

(5E)-5-benzylidene-1-butyllpyrrolidin-2-one

(E)-N-butyl-3-(2-hydroxyphenyl)acrylamide

2-Hydroxymethylpyridine

Refernces

• 1、 Hasegawa, Urara,Van Der Vlies, Andre J.,Simeoni, Eleonora,Wandrey, Christine,Hubbell, Jeffrey A.. "Carbon monoxide-releasing micelles for immunotherapy". . p. 18273 - 18280. Retrieved 2010.
• 2、 Sun, Xin,Bai, Xiao-Yan,Li, An-Zhen,Li, Bi-Jie. "Iridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives". supporting information. p. 2182 - 2187. Retrieved 2021/03/01.
• 3、 -. "SYSTEMS AND METHODS FOR INTRACELLULAR DELIVERY VIA NON-CHARGED SEQUENCE-DEFINED CELL-PENETRATING OLIGOMERS". Paragraph 0199. . Retrieved 2019/12/04.