5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

Base Information

Chemical Name:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide
CAS No.:1332875-31-6
Molecular Formula:C₂₈H₂₈ClF₃N₆O₂
Molecular Weight:573.018
Hs Code.:

Synonyms:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

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Chemical Property of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

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Technology Process of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

There total 7 articles about 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-30-5
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1332875-31-6
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; toluene; at 100 ℃; Inert atmosphere;

Reference yield:

: 1245207-40-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-31-6
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / methanol / 4 h / 20 °C

1.2: pH 7

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

3.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

3.2: 2 h / 20 °C

4.1: 1,4-dioxane / 2 h / 65 °C

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; toluene; water / 100 °C / Inert atmosphere

With oxalyl dichloride; water; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5.1: Suzuki Coupling;

Reference yield:

: 685513-51-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid

: 1332875-31-6
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(4-methoxy-benzylamino)-5-(2-trifluoromethyl-phenyl)-pyrazin-2-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

2.2: 2 h / 20 °C

3.1: 1,4-dioxane / 2 h / 65 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; toluene; water / 100 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: Suzuki Coupling;