5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

Base Information

Chemical Name:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide
CAS No.:1332875-30-5
Molecular Formula:C₂₁H₂₄BrClN₆O₂
Molecular Weight:507.818
Hs Code.:

Synonyms:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

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Chemical Property of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

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Technology Process of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

There total 6 articles about 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₄Br₂ClN₅O

: 2393-23-9
4-methoxy-benzylamine

: 1332875-30-5
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

Guidance literature:: In 1,4-dioxane; at 65 ℃; for 2h;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-30-5
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

4.2: 2 h / 20 °C

5.1: 1,4-dioxane / 2 h / 65 °C

With sulfuryl dichloride; oxalyl dichloride; water; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 685513-51-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid

: 1332875-30-5
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [5-bromo-3-(4-methoxy-benzylamino)-pyrazin-2-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.1: sodium hydride / 1,2-dimethoxyethane / 20 °C

2.2: 2 h / 20 °C

3.1: 1,4-dioxane / 2 h / 65 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;