tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

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Chemical Name:tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate
CAS No.:1350560-23-4
Molecular Formula:C₄₂H₅₂N₂O₄Si
Molecular Weight:676.971
Hs Code.:

Synonyms:tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

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Chemical Property of tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

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Technology Process of tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

There total 3 articles about tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1350560-10-9
tert-butyl ((2R,3R)-3-(benzyl(hydroxy)amino)-7-(benzyloxy)-1-((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

: 1350560-23-4
tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

Guidance literature:: tert-butyl ((2R,3R)-3-(benzyl(hydroxy)amino)-7-(benzyloxy)-1-((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate; With copper diacetate; acetic acid; zinc; at 60 ℃; for 2h;

With disodium ethylenediaminetetraacetic acid; sodium hydroxide; In water; pH=Ca. 10;
DOI:10.1021/ja2098063

Reference yield:

: 158723-49-0,188965-46-0
C₃₁H₄₀N₂O₄Si

: 1350560-23-4
tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -15 °C

1.2: 4 h / -78 °C

2.1: copper diacetate; acetic acid; zinc / 2 h / 60 °C

2.2: pH Ca_. 10

With isopropylmagnesium chloride; copper diacetate; acetic acid; zinc; In tetrahydrofuran;
DOI:10.1021/ja2098063

Reference yield:

: 22273-77-4
((but-3-yn-1-yloxy)methyl)benzene

: 1350560-23-4
tert-butyl ((2R,3R)-3-(benzylamino)-7-(benzyloxy)-1((tert-butyldiphenylsilyl)oxy)hept-4-yn-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -15 °C

1.2: 4 h / -78 °C

2.1: copper diacetate; acetic acid; zinc / 2 h / 60 °C

2.2: pH Ca_. 10

With isopropylmagnesium chloride; copper diacetate; acetic acid; zinc; In tetrahydrofuran;
DOI:10.1021/ja2098063