11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

Base Information

Chemical Name:11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one
CAS No.:1048334-57-1
Molecular Formula:C₂₇H₂₄BrClN₂O₃
Molecular Weight:539.856
Hs Code.:

Synonyms:11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

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Chemical Property of 11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

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Technology Process of 11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

There total 2 articles about 11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1047619-52-2
C₁₃H₈BrClO₂

: 1048041-42-4
C₁₄H₁₈N₂O₂

: 1048334-57-1
11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

Guidance literature:: With acetic acid; In ethanol; at 70 ℃;
DOI:10.1016/j.bmcl.2009.03.035

Reference yield:

: 1048334-57-1
11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

Guidance literature:

Reference yield: 86.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1048334-57-1
11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048334-64-0
10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

Guidance literature:: 3-chloro-3-oxopropanoic acid methyl ester; 11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one; With pyridine; In dichloromethane; for 1.5h;

With lithium hydroxide; water; In tetrahydrofuran; for 0.166667h;

With hydrogenchloride; In tetrahydrofuran; water; pH=4;