10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

Base Information

Chemical Name:10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one
CAS No.:1048334-64-0
Molecular Formula:C₃₁H₂₈BrClN₂O₆
Molecular Weight:639.93
Hs Code.:

Synonyms:10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

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Chemical Property of 10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

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Technology Process of 10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

There total 1 articles about 10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1048334-57-1
11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048334-64-0
10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

Guidance literature:: 3-chloro-3-oxopropanoic acid methyl ester; 11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one; With pyridine; In dichloromethane; for 1.5h;

With lithium hydroxide; water; In tetrahydrofuran; for 0.166667h;

With hydrogenchloride; In tetrahydrofuran; water; pH=4;

Reference yield:

: 1048334-64-0
10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048334-65-1
3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

Guidance literature:: 10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield:

: 1048334-64-0
10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048334-80-0
(R)-3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

: 1048339-33-8
(S)-3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

1.2: pH 2

2.1: carbon dioxide; isopropyl alcohol

With lithium hydroxide; water; In tetrahydrofuran; carbon dioxide; isopropyl alcohol;