3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

Base Information

Chemical Name:3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid
CAS No.:1048334-65-1
Molecular Formula:C₃₀H₂₆BrClN₂O₆
Molecular Weight:625.903
Hs Code.:

Synonyms:3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

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Chemical Property of 3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

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Technology Process of 3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

There total 2 articles about 3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1048334-64-0
10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048334-65-1
3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

Guidance literature:: 10-(3-oxo-3-methoxypropionyl)-11-[4-(2-bromophenoxy)-2-chloro-phenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield:

: 1048334-57-1
11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-dibenzo[b,e][1,4]diazepin-1-one

: 1048334-65-1
3-{11-[4-(2-bromophenoxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl}-3-oxopropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 1.5 h

1.2: 0.17 h

1.3: pH 4

2.1: lithium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

2.2: pH 2

With pyridine; lithium hydroxide; water; In tetrahydrofuran; dichloromethane;