Boc₂-Gly-Phe-Leu-OBzl

Base Information

• Chemical Name: Boc₂-Gly-Phe-Leu-OBzl
• CAS No.: 132090-35-8
• Molecular Formula: C₃₄H₄₇N₃O₈
• Molecular Weight: 625.762
• Mol file: 132090-35-8.mol

Synonyms:Boc₂-Gly-Phe-Leu-OBzl

Chemical Property of Boc₂-Gly-Phe-Leu-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc₂-Gly-Phe-Leu-OBzl

There total 15 articles about Boc₂-Gly-Phe-Leu-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) + 2-(bis(tert-butoxycarbonyl)amino)acetic acid (113568-18-6) → Boc2-Gly-Phe-Leu-OBzl (132090-35-8)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; for 5h; Ambient temperature;

Reference yield: 64.0%

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) + Boc2-Gly-ONp (132090-27-8) → Boc2-Gly-Phe-Leu-OBzl (132090-35-8)

Guidance literature:

In N,N-dimethyl-formamide; for 21h; Ambient temperature;

Reference yield:

(BOC)2Phe-OH (113568-21-1) → Boc2-Gly-Phe-Leu-OBzl (132090-35-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 80.4 percent / cyanuric fluoride, pyridine / CH₂Cl₂ / 1 h / -30 - -20 °C

2: 80 percent / diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

3: 0.74 g / trifluoroacetic acid / 1 h / 0 °C

4: diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; trifluoro-[1,3,5]triazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00067a067

upstream raw materials:

L-phenylalanyl-L-leucine benzyl ester

2-(bis(tert-butoxycarbonyl)amino)acetic acid

Boc₂-Gly-ONp

(BOC)2Gly-F

Downstream raw materials:

Leu-enkephalin

H-Gly-Gly-Phe-Leu-OBzl

Boc₂-Gly-Gly-Phe-Leu-OBzl

Boc₂-Tyr(Bzl)-Gly-Gly-Phe-Leu-OBzl