(S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

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Chemical Name:(S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate
CAS No.:1415694-92-6
Molecular Formula:C₂HF₃O₂*C₂₃H₂₄N₆O
Molecular Weight:514.507
Hs Code.:

Synonyms:(S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

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Chemical Property of (S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

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Technology Process of (S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

There total 6 articles about (S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 443776-76-9
(3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol

: 1415695-25-8
(S)-6-Chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-[1,2,4]-triazolo[1,5-a]pyridin-8-amine

: 76-05-1
trifluoroacetic acid

: 1415694-92-6
(S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Guidance literature:: (3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol; (S)-6-Chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-[1,2,4]-triazolo[1,5-a]pyridin-8-amine; With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; for 18h; Reflux; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1415694-92-6
(S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; silver sulfate / 20 °C

2.1: isopropyl alcohol / 5 h / 20 - 100 °C

2.2: 16 h / 50 - 60 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / xylene / 8 h / 140 °C / Reflux

5.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / Reflux; Inert atmosphere

With iodine; caesium carbonate; silver sulfate; trifluoroacetic anhydride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol; xylene;

Reference yield:

: 480425-35-2
methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1415694-92-6
(S)-(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

1.2: 0 °C

2.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / Reflux; Inert atmosphere

With lithium aluminium tetrahydride; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;