(2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Base Information

Chemical Name:(2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol
CAS No.:135218-66-5
Molecular Formula:C₂₉H₃₈O₄Si
Molecular Weight:478.704
Hs Code.:

Synonyms:(2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

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Technology Process of (2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

There total 5 articles about (2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: C₃₅H₅₂O₄Si₂

: 135218-66-5
(2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 60 ℃; for 8h;
DOI:10.1016/S0040-4039(00)97081-3

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 135218-66-5
(2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / EtN(i-Pr)2 / CH₂Cl₂ / Ambient temperature

2: 1) O₃, 2) Me₂S / 1) CH₂Cl₂/MeOH, -78 deg C, 2) room temp., 5 h

3: tetrahydrofuran / -78 °C / other methyl-metal compounds, solvents, temperatures

4: 88 percent / imidazole / dimethylformamide / 10 h / 85 °C

5: 75 percent / pyridinium tosylate / ethanol / 8 h / 60 °C

With 1H-imidazole; dimethylsulfide; pyridinium p-toluenesulfonate; ozone; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)97081-3

Reference yield:

: 138513-54-9
(R)-(E)-2-<<(Benzyloxy)methoxy>methyl>-1-<(tert-butyldimethylsilyl)oxy>-5-methylhex-3-ene

: 135218-66-5
(2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) O₃, 2) Me₂S / 1) CH₂Cl₂/MeOH, -78 deg C, 2) room temp., 5 h

2: tetrahydrofuran / -78 °C / other methyl-metal compounds, solvents, temperatures

3: 88 percent / imidazole / dimethylformamide / 10 h / 85 °C

4: 75 percent / pyridinium tosylate / ethanol / 8 h / 60 °C

With 1H-imidazole; dimethylsulfide; pyridinium p-toluenesulfonate; ozone; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)97081-3