tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate
CAS No.:1584151-47-2
Molecular Formula:C₂₁H₂₄N₄O₄S
Molecular Weight:428.512
Hs Code.:

Synonyms:tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

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Chemical Property of tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

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Technology Process of tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

There total 3 articles about tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 6290-49-9
methyl methoxyacetate

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

: 1584151-47-2
tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

Guidance literature:: methyl methoxyacetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.416667h; Inert atmosphere;

tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate; With Martins sulfurane; In tetrahydrofuran; at 20 ℃; for 3h; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/jo500284n

Reference yield:

: 3938-96-3
ethyl 2-methoxyacetate

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

: 1584151-47-2
tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

Guidance literature:: ethyl 2-methoxyacetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/acsmedchemlett.5b00193

Reference yield:

: 1625677-96-4
tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

: 1584151-47-2
tert-butyl(3-(6-methoxy-5-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / chloroform / 16 h / 60 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2.2: -78 - 20 °C

With manganese(IV) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform;
DOI:10.1021/acsmedchemlett.5b00193