(4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

Base Information

Chemical Name:(4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate
CAS No.:1313491-67-6
Molecular Formula:C₂₆H₂₆NO₃P
Molecular Weight:431.471
Hs Code.:

Synonyms:(4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

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Chemical Property of (4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

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Technology Process of (4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

There total 5 articles about (4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 75-36-5
acetyl chloride

: (4'S)-2-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydro-oxazol-4'-yl]-propan-2-ol

: 1313491-67-6
(4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

Guidance literature:: (4'S)-2-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydro-oxazol-4'-yl]-propan-2-ol; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

acetyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 1313491-67-6
(4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 2.5 h / 0 °C

2.1: tetrahydrofuran; diethyl ether / 18 h / 0 - 20 °C

2.2: 0 °C / Saturated solution

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C

4.1: tetrahydrofuran / 2 h / 0 °C

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 24 h / 0 - 20 °C

With potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 179117-11-4
(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

: 1313491-67-6
(4'S)-1-methyl-1-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydrooxazol-4'-yl]-ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C

2.1: tetrahydrofuran / 2 h / 0 °C

3.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 24 h / 0 - 20 °C

With potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.02.021