3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Base Information

Chemical Name:3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine
CAS No.:853748-73-9
Molecular Formula:C₃₇H₆₅N₅O₆Si₃
Molecular Weight:760.209
Hs Code.:

3',5',O<sup>6</sup>-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Synonyms:3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Suppliers and Price of 3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Chemical Property:

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Technology Process of 3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

There total 4 articles about 3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 192316-91-9
2'-O-(2-benzyloxyethyl)guanosine

: 853748-73-9
3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jo050061l

Reference yield:

: 1462-37-9
bromoethyl-2-benzyl ether

: 853748-73-9
3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / NaH / various solvent(s); dimethylformamide / 18 h

2: 82 percent / adenosine deaminase type II; Tris; sodium phosphate / dimethylsulfoxide / 36 h / 20 °C

3: 73 percent / imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; adenosine deaminase type II; sodium hydride; sodium phosphate; 2-amino-2-hydroxymethyl-1,3-propanediol; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo050061l

Reference yield:

: 853748-72-8
2'-O-(2-benzyloxyethyl)-2-aminoadenosine

: 853748-73-9
3',5',O⁶-tris(tert-butyldimethylsilyl)-2'-O-(2-benzyloxyethyl)guanosine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / adenosine deaminase type II; Tris; sodium phosphate / dimethylsulfoxide / 36 h / 20 °C

2: 73 percent / imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; adenosine deaminase type II; sodium phosphate; 2-amino-2-hydroxymethyl-1,3-propanediol; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo050061l