(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Chemical Name:(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester
CAS No.:148432-35-3
Molecular Formula:C₄₄H₆₂N₂O₇
Molecular Weight:730.985
Hs Code.:

(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Synonyms:(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Chemical Property of (S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Technology Process of (S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

There total 4 articles about (S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3587-60-8
Benzyloxymethyl chloride

: 148432-27-3
(S)-2-[(E)-(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-hydroxy-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

: 148432-35-3
(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Heating;

Reference yield:

: 118535-62-9
(S)-(-)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine

: 148432-35-3
(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / cyclohexane

2: 1) LDA, LiBr / 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h

3: 94 percent / nBu₄NI, iPr₂NEt / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In dichloromethane; cyclohexane;

Reference yield:

: 145656-72-0
2,6-di-tert-butyl-4-methoxyphenyl pyruvate

: 148432-35-3
(S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / cyclohexane

2: 1) LDA, LiBr / 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h

3: 94 percent / nBu₄NI, iPr₂NEt / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In dichloromethane; cyclohexane;