prednisone

Base Information

• Chemical Name: prednisone
• CAS No.: 1092578-27-2
• Molecular Formula: C₂₈H₂₉NO₉
• Molecular Weight: 523.54
• Mol file: 1092578-27-2.mol

Synonyms:prednisone

Chemical Property of prednisone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of prednisone

There total 1 articles about prednisone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Prednison (53-03-2) + 4-Nitrophenyl chloroformate (7693-46-1) → prednisone (1092578-27-2)

Guidance literature:

With dmap; In dichloromethane; at 0 ℃;

DOI:10.1016/j.ejmech.2014.07.073

Reference yield: 77.0%

prednisone (1092578-27-2) + N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) + chlorambucil (305-03-3) → C39H48Cl2N2O10

Guidance literature:

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine; With 2-chlorotrityl resin; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h; Cl-Trt resin Inert atmosphere;

With methanol; In dichloromethane; Cl-Trt resin

prednisone; chlorambucil; Further stages;

DOI:10.1016/j.ejmech.2014.07.073

Reference yield:

prednisone (1092578-27-2) + C26H36N4O13 → C48H60N4O19 (1092578-28-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

upstream raw materials:

Prednison

4-Nitrophenyl chloroformate

Downstream raw materials:

C₄₈H₆₀N₄O₁₉

Refernces

• 1、 -. "NOVEL ANTI-INFLAMMATORY PRO-DRUGS". Page/Page column 29. . Retrieved 2009/01/24.