(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

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Chemical Name:(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate
CAS No.:1218770-05-8
Molecular Formula:C₃₃H₄₀N₂O₅S
Molecular Weight:576.757
Hs Code.:

Synonyms:(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

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Chemical Property of (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

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Technology Process of (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

There total 8 articles about (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1489278-81-0
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(5-methyl-4-(2-methyl-3-oxoprop-1-enyl)thiazol-2-yl)ethylcarbamate

: 107905-52-2
ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate

: 1218770-05-8
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(5-methyl-4-(2-methyl-3-oxoprop-1-enyl)thiazol-2-yl)ethylcarbamate; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489290-63-2
C₂₅H₃₀N₂O₄S

: 1218770-05-8
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

2.2: 4 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

5.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

5.2: 2 h / -78 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; potassium hexamethylsilazane; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: C₂₈H₃₄N₂O₄S

: 1218770-05-8
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

With 18-crown-6 ether; potassium hexamethylsilazane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1016/j.ejmech.2013.09.017