(3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole

Base Information

• Chemical Name: (3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole
• CAS No.: 1224588-07-1
• Molecular Formula: C₁₅H₂₀O₅
• Molecular Weight: 280.321

Synonyms:(3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole

Chemical Property of (3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole

Chemical Property:

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Technology Process of (3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole

There total 1 articles about (3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + (3aR,6R,6aR)-6-(2-methoxypropan-2-yloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (1224588-06-0) → (3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole (1224588-07-1)

Guidance literature:

With sulfuric acid; for 0.0833333h;

DOI:10.1016/j.tet.2010.01.107

Reference yield: 59.0%

(3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole (1224588-07-1) → (3aR,6S,6aS)-6-iodomethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole (1224587-89-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In toluene; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2010.01.107

Reference yield: 59.0%

(3aR,6R,6aR)-6-hydroxymethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole (1224588-07-1) + p-toluenesulfonyl chloride (98-59-9) → (3aR,6R,6aR)-4-methoxy-2,2-dimethyl-4-phenyl-6-((p-toluenesulfonyloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxole (1224588-08-2)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃;

DOI:10.1016/j.tet.2010.01.107

upstream raw materials:

methanol

(3aR,6R,6aR)-6-(2-methoxypropan-2-yloxy)methyl-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Downstream raw materials:

(3aR,6S,6aS)-6-iodomethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole

(3aR,6R,6aR)-4-methoxy-2,2-dimethyl-4-phenyl-6-((p-toluenesulfonyloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxole

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