N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

Base Information

Chemical Name:N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine
CAS No.:952065-36-0
Molecular Formula:C₂₆H₄₂N₄O₉S
Molecular Weight:586.707
Hs Code.:

Synonyms:N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

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Technology Process of N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

There total 1 articles about N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 102185-38-6,200122-49-2
Nα-(t-butyloxycarbonyl)-Nω-(4-methoxy-2,3,6-trimethylbenzenesulphonyl)-L-arginine

: 952065-36-0
N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

Guidance literature:: With sodium hydride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.tet.2007.06.082

Reference yield: 66.0%

: 952065-36-0
N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 183442-79-7
N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine-N,O-dimethylhydroxyamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2007.06.082

Reference yield:

: 952065-36-0
N-α,N'-ω'-di(t-butyloxycarbonyl)-N-ω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-arginine

: C₃₀H₄₈N₄O₉S

Guidance literature:: Multi-step reaction with 2 steps

1.1: 66 percent / triethylamine; BOP / CH₂Cl₂ / 3 h / 20 °C

2.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

2.2: 14 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

With lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Weinreb amidation;
DOI:10.1016/j.tet.2007.06.082