(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

Base Information

Chemical Name:(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol
CAS No.:147189-95-5
Molecular Formula:C₁₆H₂₆Cl₂O₂Si
Molecular Weight:349.373
Hs Code.:

Synonyms:(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

Suppliers and Price of (1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

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Technology Process of (1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

There total 3 articles about (1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 147189-94-4
(1R)-(3,4-Dichlorophenyl)-1,4-butanediol

: 147189-95-5
(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 18h; ice-bath temp. to r.t.;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 50597-19-8
3-(3,4-dichlorobenzoyl)-propionic acid

: 147189-95-5
(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄, 1N aq. NaOH / 18 h / Ambient temperature

2: 10.33 g / LiAlH₄ / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C

3: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t.

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 118528-87-3
4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid

: 147189-95-5
(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

Guidance literature:: Multi-step reaction with 2 steps

1: 10.33 g / LiAlH₄ / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C

2: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t.

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88330-7