2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

• Chemical Name: 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
• CAS No.: 635699-40-0
• Molecular Formula: C₁₁H₁₁Cl₂N₃O
• Molecular Weight: 272.134

Synonyms:2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Chemical Property of 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 1 articles about 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (635699-40-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / ethanol / 24 h / Heating / reflux

2: trichlorophosphate / 5 h

3: carbonochloridic acid, chloromethyl ester; triethylamine / 1,2-dichloro-ethane / 5 h / Heating / reflux

4: triethylamine / dichloromethane / 1 h / 20 °C

With sodium methylate; carbonochloridic acid, chloromethyl ester; triethylamine; trichlorophosphate; In ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (635699-40-0) + 2,4-dichloro-benzenemethanamine (95-00-1) → 2-chloro-4-(2,4-dichlorobenzylamino)-6-(cyclopropylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:

With triethylamine; In tetrahydrofuran; chloroform; at 40 ℃; for 20h; Product distribution / selectivity; Sealed;

Reference yield:

2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (635699-40-0) → {1,4-bis[4-(3-chlorobenzylamino)-6-cyclopropylcarbonyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]piperazine}

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 20 h / 40 °C

2: sodium carbonate / 1,4-dioxane / 168 h / 90 °C

With sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

C₉H₁₄O₃NC₆H₅

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