(S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

Base Information

Chemical Name:(S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate
CAS No.:37169-42-9
Molecular Formula:C₂₄H₂₃NO₆
Molecular Weight:421.45
Hs Code.:
DSSTox Substance ID:DTXSID701161868

Synonyms:37169-42-9;(S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate;benzyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(3,4-dihydroxyphenyl)propanoate;benzyl (2S)-3-(3,4-dihydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoate;SCHEMBL7437357;DTXSID701161868;MFCD30471771;AKOS030627980;AS-73304;W11930;Benzyl (S)-2-(Cbz-amino)-3-(3,4-dihydroxyphenyl)propanoate;3-Hydroxy-N-[(phenylmethoxy)carbonyl]-L-tyrosine phenylmethyl ester;(S)-Benzyl2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate;(S)-BenZyl 2-(((benZyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate (CbZ-L-Tyr(3-OH)-OBZl)

Suppliers and Price of (S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:421.15253745
Heavy Atom Count:31
Complexity:558

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC(=O)C(CC2=CC(=C(C=C2)O)O)NC(=O)OCC3=CC=CC=C3
Isomeric SMILES:C1=CC=C(C=C1)COC(=O)[C@H](CC2=CC(=C(C=C2)O)O)NC(=O)OCC3=CC=CC=C3

Technology Process of (S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

There total 6 articles about (S)-Benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 30033-25-1
(S)-2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoic acid

: 37169-42-9
(S)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: With CsCO₃; In water; N,N-dimethyl-formamide; Yield given; Ambient temperature;
DOI:10.1016/S0040-4020(98)00590-0

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 37169-42-9
(S)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃ / H₂O; dioxane / Ambient temperature

2: CsCO₃ / H₂O; dimethylformamide / Ambient temperature

With sodium hydrogencarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00590-0

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 501-53-1,94274-21-2
benzyl chloroformate

: 37169-42-9
(S)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 25 °C / Large scale

2: caesium carbonate / 1 h / 20 °C

With sodium hydrogencarbonate; caesium carbonate; In 1,4-dioxane; water;