Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

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Chemical Name:Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester
CAS No.:117068-43-6
Molecular Formula:C₃₀H₃₂N₂O₇S
Molecular Weight:564.659
Hs Code.:

Synonyms:Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

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Chemical Property of Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

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Technology Process of Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

There total 4 articles about Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124-63-0
methanesulfonyl chloride

: 117068-42-5
(R,S)-1-<1-<2-(trityloxy)ethoxy>-3-hydroxypropyl>thymine

: 117068-43-6
Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

Guidance literature:: With pyridine; at 5 ℃;
DOI:10.1021/jm00121a015

Reference yield:

: 18325-45-6
trityl 2-hydroxyethyl ether

: 117068-43-6
Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Et₃N / diethyl ether / 67 h / Ambient temperature

2: 83 percent / DBU / acetonitrile; dimethylsulfoxide / 504 h / Ambient temperature

3: 81 percent / LiAlH₄ / tetrahydrofuran

4: 94 percent / pyridine / 5 °C

With pyridine; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00121a015

Reference yield:

: 117068-40-3
methyl (E)-3-<2-(trityloxy)ethoxy>propenoate

: 117068-43-6
Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / DBU / acetonitrile; dimethylsulfoxide / 504 h / Ambient temperature

2: 81 percent / LiAlH₄ / tetrahydrofuran

3: 94 percent / pyridine / 5 °C

With pyridine; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00121a015