(E)-2'-hydroxy-4-methoxychalcone epoxide

Base Information

• Chemical Name: (E)-2'-hydroxy-4-methoxychalcone epoxide
• CAS No.: 129878-46-2
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.285
• Mol file: 129878-46-2.mol

Synonyms:(E)-2'-hydroxy-4-methoxychalcone epoxide

Chemical Property of (E)-2'-hydroxy-4-methoxychalcone epoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2'-hydroxy-4-methoxychalcone epoxide

There total 1 articles about (E)-2'-hydroxy-4-methoxychalcone epoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[E]-3-(p-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (34000-29-8) → (E)-2'-hydroxy-4-methoxychalcone epoxide (129878-46-2)

Guidance literature:

With 3,3-dimethyldioxirane; In dichloromethane; acetone; at 20 ℃; for 21h;

Reference yield:

(E)-2'-hydroxy-4-methoxychalcone epoxide (129878-46-2) → 4'-(methoxy)-3-hydroxyflavone (6889-78-7) + 2,3-trans-3-hydroxy-4'-methoxyflavan-4-one (6515-31-7,35090-82-5,95908-47-7,110222-22-5,139068-07-8)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 8h; Yield given. Yields of byproduct given;

DOI:10.1021/jo960163z

Reference yield:

(E)-2'-hydroxy-4-methoxychalcone epoxide (129878-46-2) → 2,3-trans-3-hydroxy-4'-methoxyflavan-4-one (6515-31-7,35090-82-5,95908-47-7,110222-22-5,139068-07-8)

Guidance literature:

In methanol; Yield given; Heating;

DOI:10.1016/S0040-4020(97)00506-1

upstream raw materials:

[E]-3-(p-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Downstream raw materials:

4'-(methoxy)-3-hydroxyflavone

2,3-trans-3-hydroxy-4'-methoxyflavan-4-one

Refernces

• 1、 Burke, Anthony J.,O'Sullivan, W. Ivo. "Flavonoid epoxides. Part 20. Some unusual reactions of dimethyldioxirane (DMD) with flavonoid compounds". . p. 8491 - 8500. Retrieved 2007/10/03.
• 2、 Gupta, D. R.,Kamaluddin,Naithani, Shobha. "EPOXIDATION OF SOME α,β-UNSATURATED CARBONYL SYSTEMS WITH HYPOCHLORITE UNDER PHASE TRANSFER CATALYSIS CONDITIONS". . p. 747 - 751. Retrieved 2007/10/02.