Technology Process of (R)-2-{(1S,3S,4R)-2-[1-Methoxy-meth-(E)-ylidene]-4-methyl-3-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester
There total 9 articles about (R)-2-{(1S,3S,4R)-2-[1-Methoxy-meth-(E)-ylidene]-4-methyl-3-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hexamethylsilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at 50 ℃;
for 24h;
DOI:10.1016/S0040-4039(02)02500-5
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dicyclohexylborane / tetrahydrofuran / 168 h / 0 °C
1.2: 82 percent / H2O2; OH(1-)
2.1: 80 percent / CrO3; H2SO4 / acetone / 0 °C
3.1: KI; NaHCO3 (aq.) / 48 h
4.1: 72 percent / (Me3Si)3SiH; AIBN / toluene
5.1: BF3*Et2O / CH2Cl2 / 0 °C
6.1: NaOH (10 percent in MeOH) / Heating
7.1: diethyl ether
8.1: 89 percent / PCC / CH2Cl2 / 0 °C
9.1: 45 percent / KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 24 h / 50 °C
With
chromium(VI) oxide; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; sulfuric acid; boron trifluoride diethyl etherate; bis(cyclohexanyl)borane; potassium hexamethylsilazane; sodium hydrogencarbonate; pyridinium chlorochromate; potassium iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; acetone; toluene;
2.1: Jones oxidation;
DOI:10.1016/S0040-4039(02)02500-5
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 80 percent / CrO3; H2SO4 / acetone / 0 °C
2: KI; NaHCO3 (aq.) / 48 h
3: 72 percent / (Me3Si)3SiH; AIBN / toluene
4: BF3*Et2O / CH2Cl2 / 0 °C
5: NaOH (10 percent in MeOH) / Heating
6: diethyl ether
7: 89 percent / PCC / CH2Cl2 / 0 °C
8: 45 percent / KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 24 h / 50 °C
With
chromium(VI) oxide; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; sulfuric acid; boron trifluoride diethyl etherate; potassium hexamethylsilazane; sodium hydrogencarbonate; pyridinium chlorochromate; potassium iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; acetone; toluene;
1: Jones oxidation;
DOI:10.1016/S0040-4039(02)02500-5
