(2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

Base Information

Chemical Name:(2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride
CAS No.:313696-94-5
Molecular Formula:C₃₁H₃₂ClN₃O₆Si
Molecular Weight:606.15
Hs Code.:

Synonyms:(2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

Chemical Property:

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Technology Process of (2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

There total 7 articles about (2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 194232-63-8
2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazole-4-carbaldehyde

: 313696-94-5
(2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / TiCl₄ / CH₂Cl₂ / 24 h / -78 - 20 °C

2: 93 percent / silver(I) oxide / 10 h / Heating

3: OsO₄; trimethylamine N-oxide dihydrate; t-BuOH / tetrahydrofuran; H₂O; toluene / 4 h / 20 °C

4: 773 mg / Pb(OAc)4; K₂CO₃ / diethyl ether / 0.25 h / 0 °C

5: NaClO₂

6: (COCl)2 / dimethylformamide

With lead(IV) acetate; sodium chlorite; osmium(VIII) oxide; oxalyl dichloride; trimethylamine-N-oxide; titanium tetrachloride; potassium carbonate; silver(l) oxide; tert-butyl alcohol; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja002377a

Reference yield:

: (2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionic acid

: 313696-94-5
(2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

Guidance literature:: With oxalyl dichloride; In N,N-dimethyl-formamide;
DOI:10.1021/ja002377a

Reference yield:

: 262279-31-2
(5S,6S)-(E)-methyl 6-methoxy-5-methyl-6-(2-tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-hex-3-enoate

: 313696-94-5
(2R,3S)-3-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3-methoxy-2-methyl-propionyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: OsO₄; trimethylamine N-oxide dihydrate; t-BuOH / tetrahydrofuran; H₂O; toluene / 4 h / 20 °C

2: 773 mg / Pb(OAc)4; K₂CO₃ / diethyl ether / 0.25 h / 0 °C

3: NaClO₂

4: (COCl)2 / dimethylformamide

With lead(IV) acetate; sodium chlorite; osmium(VIII) oxide; oxalyl dichloride; trimethylamine-N-oxide; potassium carbonate; tert-butyl alcohol; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja002377a