benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide

Base Information

• Chemical Name: benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide
• CAS No.: 96386-78-6
• Molecular Formula: C₂₇H₂₈N₆O₄
• Molecular Weight: 500.557
• Mol file: 96386-78-6.mol

Synonyms:benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide

Chemical Property of benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide

There total 1 articles about benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2S-2-benzyloxycarbonylamino-2-(naphth-1-yl)methyl-acetic acid (65365-15-3,96402-43-6) + L-Histidine methyl ester (1499-46-3) → benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide (96386-78-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; hydrazine; Multistep reaction; 2.) MeOH;

DOI:10.1246/cl.1985.1041

Reference yield:

L-leucinal semicarbazone + N-benzyloxycarbonyl-L-leucinal semicarbazone + N-benzyloxycarbonyl-3-(1-naphthyl)-L-alanyl-L-histidine azide + benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide (96386-78-6) → Z-Nal(1)-His-Leucinal (89435-66-5)

Guidance literature:

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; sodium hydrogencarbonate; isopentyl nitrite; In 1,4-dioxane; N-methyl-acetamide; diethyl ether; acetic acid;

Reference yield:

Boc-Sta-OBz (100002-37-7) + benzyloxycarbonyl-L-<3-(1-naphthyl)>alanyl-L-histidine hydrazide (96386-78-6) → benzyl 4(S)-[N-benzyloxycarbonyl-3-(1-naphthyl)-L-alanyl-L-histidyl]amino-3(S)-hydroxy-6-methylheptanoate

Guidance literature:

In diethyl ether;

upstream raw materials:

2S-2-benzyloxycarbonylamino-2-(naphth-1-yl)methyl-acetic acid

L-Histidine methyl ester

Downstream raw materials:

Z-Nal⁽¹⁾-His-Leucinal semicarbazone

Z-Nal⁽¹⁾-His-Leucinal

(2S,3S)-3-[N-Benzyloxycarbonyl-3-(1-naphthyl)-L-alanyl-L-histidyl]amino-2-hydroxy-5-methylhexanol

Benzyloxycarbonyl-L-(1-naphthyl)alanyl-L-histidyl-L-leucinol