{2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester
• CAS No.: 865357-79-5
• Molecular Formula: C₂₃H₃₆N₄O₇
• Molecular Weight: 480.561
• Mol file: 865357-79-5.mol

Synonyms:{2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester

Chemical Property of {2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester

There total 2 articles about {2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-BOC-1,2-diaminoethane (57260-73-8) + anisole-2,6-dicarboxylic acid bis acid chloride (2390-40-1) → {2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester (865357-79-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1039/b506756a

Reference yield:

2-methoxyisophthalic acid (1951-38-8) → {2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester (865357-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / SOCl₂; DMF / 8 h / Heating

2: 86 percent / Et₃N / CH₂Cl₂ / 72 h / 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1039/b506756a

Reference yield: 90.0%

{2-[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-2-methoxy-benzoylamino]-ethyl}-carbamic acid tert-butyl ester (865357-79-5) → N,N'-bis-(2-amino-ethyl)-2-hydroxy-isophthalamide (512780-13-1)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1039/b506756a

upstream raw materials:

N-BOC-1,2-diaminoethane

anisole-2,6-dicarboxylic acid bis acid chloride

2-methoxyisophthalic acid

Downstream raw materials:

N,N'-bis-(2-amino-ethyl)-2-hydroxy-isophthalamide