methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate

Base Information

• Chemical Name: methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate
• CAS No.: 887969-51-9
• Molecular Formula: C₁₁H₁₄FNO₃
• Molecular Weight: 227.235
• Mol file: 887969-51-9.mol

Synonyms:methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate

Chemical Property of methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate

There total 1 articles about methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-amino-2-fluoromethyl-3-(3-hydroxyphenyl)-propionic acid (73800-86-9,73804-77-0) → methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate (887969-51-9)

Guidance literature:

With thionyl chloride; at 60 ℃; for 96h;

Reference yield:

methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate (887969-51-9) + di-tert-butyl dicarbonate (24424-99-5) → methyl 2-tert-butoxycarbonylamino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate (887969-52-0)

Guidance literature:

methyl 2-amino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate; di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; tert-butyl alcohol; at 60 ℃; for 1.5h;

With citric acid; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

methanol

2-amino-2-fluoromethyl-3-(3-hydroxyphenyl)-propionic acid

Downstream raw materials:

methyl 2-tert-butoxycarbonylamino-2-(fluoromethyl)-3-(3-hydroxyphenyl)propanoate