2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester
CAS No.:94193-06-3
Molecular Formula:C₂₇H₃₈N₄O₅
Molecular Weight:498.623
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Suppliers and Price of 2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

There total 8 articles about 2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 94192-60-6
N-cyclohexyl-N-(2-hydroxyethyl)-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramide

: 94193-06-3
2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Guidance literature:: With dmap; In pyridine; for 1h; Ambient temperature;
DOI:10.1021/jm00385a012

Reference yield:

: 2842-38-8
cyclohexyl(2-(hydroxy)ethyl)amine

: 94193-06-3
2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Na₂CO₃ / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: H₂ / 10percent Pd/C / ethanol

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

6: 70 percent / DMAP / pyridine / 1 h / Ambient temperature

With dmap; ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol;
DOI:10.1021/jm00385a012

Reference yield:

: 94193-39-2
N-Cyclohexyl-4-(3-formyl-4-nitro-phenoxy)-N-(2-hydroxy-ethyl)-butyramide

: 94193-06-3
2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AcONa / ethanol / 0.5 h

2: NaBH₃CN / ethanol / 3 h

3: H₂ / 10percent Pd/C / ethanol

4: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

5: 70 percent / DMAP / pyridine / 1 h / Ambient temperature

With dmap; ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; palladium on activated charcoal; In pyridine; ethanol;
DOI:10.1021/jm00385a012