1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

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Chemical Name:1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one
CAS No.:1185280-90-3
Molecular Formula:C₂₃H₁₉N₅O₂S
Molecular Weight:429.502
Hs Code.:

Synonyms:1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

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Chemical Property of 1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

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Technology Process of 1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

There total 16 articles about 1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1185281-15-5
(Z)-1,7-dimethyl-3-(2-methyl-5-(1-(methylthio)-3-oxo-3-(thiazol-2-yl)prop-1-enylamino)phenyl)-1,6-naphthyridin-2(1H)-one

: 1185280-90-3
1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: With potassium carbonate; In 1,4-dioxane; at 150 ℃; for 30h;

Reference yield:

: 409082-11-7
2-(2-methyl-5-nitrophenyl)acetonitrile

: 1185280-90-3
1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; potassium hydroxide / methanol / 14 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux

2.2: pH > 12

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

6.1: dichloromethane / 1 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

7.2: 0.17 h

8.1: potassium carbonate / 1,4-dioxane / 30 h / 150 °C

With hydrogenchloride; water; hydrogen; sodium hydride; potassium carbonate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 449811-28-3
ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate

: 1185280-90-3
1,7-dimethyl-3-(2-methyl-5-(5-(thiazol-2-yl)isoxazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

1.2: 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

5.1: dichloromethane / 1 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

6.2: 0.17 h

7.1: potassium carbonate / 1,4-dioxane / 30 h / 150 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;