4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 872273-46-6
• Molecular Formula: C₁₄H₂₄N₂O₃
• Molecular Weight: 268.356
• Mol file: 872273-46-6.mol

Synonyms:4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester

There total 8 articles about 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl acetoacetate (141-97-9) + urea (57-13-6) + cyclohexanecarbaldehyde (2043-61-0) → 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester (872273-46-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; for 2.5h; Heating;

DOI:10.1002/jhet.5570450448

Reference yield:

→ 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester (872273-46-6)

Guidance literature:

With ethanol; copper barium chromium oxide; at 200 ℃; under 147102 Torr; 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester of mp: 181-184.5 degree; Hydrogenation;

DOI:10.1021/ja01320a058

Reference yield:

JGP-I-80A (853782-98-6) → 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester (872273-46-6)

Guidance literature:

With ethanol; nickel; at 145 ℃; under 147102 Torr; 4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester of mp: 181-184.5 degree; Hydrogenation;

DOI:10.1021/ja01320a058

upstream raw materials:

JGP-I-80A

4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid

JGP-I-142C

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

Downstream raw materials:

4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid