JGP-I-80A

Base Information

• Chemical Name: JGP-I-80A
• CAS No.: 853782-98-6
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.309
• Mol file: 853782-98-6.mol

Synonyms:JGP-I-80A

Chemical Property of JGP-I-80A

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of JGP-I-80A

There total 4 articles about JGP-I-80A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl acetoacetate (141-97-9) + benzaldehyde (100-52-7) + urea (57-13-6) → JGP-I-80A (853782-98-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; for 1.5h; Heating;

DOI:10.1002/jhet.5570450448

Reference yield:

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6,5395-36-8) → JGP-I-80A (853782-98-6)

Guidance literature:

With copper oxide barium oxide-chromium oxide catalyst; at 200 ℃; under 147102 Torr; 4-methyl-2-oxo-6-phenyl-hexahydro-pyrimidine-5-carboxylic acid ethyl ester of mp: 233 degree; Hydrogenation;

DOI:10.1021/ja01320a058

Reference yield:

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6,5395-36-8) → JGP-I-80A (853782-98-6)

Guidance literature:

With copper oxide barium oxide-chromium oxide catalyst; at 200 ℃; under 147102 Torr; 4-methyl-2-oxo-6-phenyl-hexahydro-pyrimidine-5-carboxylic acid ethyl ester of mp: 179 degree; Hydrogenation;

DOI:10.1021/ja01320a058

upstream raw materials:

JGP-I-142C

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

ethyl acetoacetate

benzaldehyde

Downstream raw materials:

JGP-I-142C

4-cyclohexyl-6-methyl-2-oxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester