4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester
CAS No.:83704-99-8
Molecular Formula:C₁₉H₂₃F₃N₆O₄
Molecular Weight:456.425
Hs Code.:

Synonyms:4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of 4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

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Technology Process of 4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

There total 13 articles about 4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6959-76-8
3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid

: 83704-99-8
4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 100 percent / H₂ / PtO₂ / acetic acid / 18 h / 2327.2 Torr

2: 90 percent / 18 h / Ambient temperature

3: thionyl chloride / benzene / 1 h / Heating

4: diethyl ether / 1 h / 25 °C

5: HBr / diethyl ether

6: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

7: p-toluenesulfonic acid / benzene / 6 h / Heating

8: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

9: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

10: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

11: 70 percent / sodium ditionite / dimethylformamide; H₂O / 0.33 h / 55 °C

12: pyridine, concd. HCl / methanol / 1 h / Heating

13: air / methanol / 4 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; sodium azide; sodium dithionite; air; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00356a004

Reference yield:

: 83704-89-6
N-(4-carbethoxycyclohexyl)-β-alanine

: 83704-99-8
4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 90 percent / 18 h / Ambient temperature

2: thionyl chloride / benzene / 1 h / Heating

3: diethyl ether / 1 h / 25 °C

4: HBr / diethyl ether

5: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

6: p-toluenesulfonic acid / benzene / 6 h / Heating

7: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

8: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

9: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

10: 70 percent / sodium ditionite / dimethylformamide; H₂O / 0.33 h / 55 °C

11: pyridine, concd. HCl / methanol / 1 h / Heating

12: air / methanol / 4 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; sodium azide; sodium dithionite; air; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00356a004

Reference yield:

: 83704-92-1
1-bromo-4-butane-2-one

: 83704-99-8
4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

2: p-toluenesulfonic acid / benzene / 6 h / Heating

3: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

4: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

5: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

6: 70 percent / sodium ditionite / dimethylformamide; H₂O / 0.33 h / 55 °C

7: pyridine, concd. HCl / methanol / 1 h / Heating

8: air / methanol / 4 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium azide; sodium dithionite; air; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00356a004