tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate
CAS No.:894802-17-6
Molecular Formula:C₂₂H₃₄N₄O₃
Molecular Weight:402.537
Hs Code.:

Synonyms:tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

There total 4 articles about tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 894802-18-7
(S)-3-(piperazin-1-ylmethyl)piperidine-1-carboxylic acid tert-butylester

: 103-71-9
phenyl isocyanate

: 894802-17-6
tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

Guidance literature:: In toluene; at 20 ℃; for 20h;

Reference yield:

: 115994-87-1
piperazine-1-carboxylic acid phenyl amide

: 194726-46-0
(3R)-3-formylpiperidine-1-carboxylic acid tert-butyl ester

: 894802-17-6
tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2012.04.118

Reference yield:

: 295341-38-7
tert-butyl 4-(phenylcarbamoyl)piperazine-1-carboxylate

: 894802-17-6
tert-butyl (3S)-3-{[4-(anilinocarbonyl)piperazin-1-yl]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2012.04.118